Abstract: Plastic waste has given rise to numerous environmental issues due to its non-biodegradable nature. This research suggested the incorporation of polyvinyl chloride (PVC) plastic powder as partial cement replacement in concrete. The replacement levels of PVC waste powder (PWP) were 0%, 4%, 8%, 12%, and 16% by mass of cement. The concrete was cured for 7, 14 and 28 days before being subjected to mechanical strength tests (compressive and flexural strengths) and durability tests (porosity, water absorption, gas permeability, chloride attack tests). Results revealed that the workability of concrete with substitution of PWP as partial cement replacement increased in which replacing 16% of cement with PWP increased the workability by 56% as compared to the control specimen. The mechanical strength of concrete and durability decreased with the increase in PWP content. Nevertheless, up to 12% of PWP can be added into the concrete as the compressive strength was only 9% lower than the control specimen. All specimens achieved the required strength of 13.8 MPa to be classified as loadbearing concrete masonry units as specified in ASTM C90 – 14. Overall, only low quantities of PWP should be used to replace cement in concrete to maintain the quality of the concrete.